|
KMID : 1102220160350040219
|
|
Kidney Research and Clinical Practice
2016 Volume.35 No. 4 p.219 ~ p.228
|
|
|
Plasma renin activity and risk of cardiovascular and mortality outcomes among individuals with elevated and nonelevated blood pressure
|
|
Bhandari Simran K.
Batech Michael
Shi Jiaxiao
Jacobsen Steven J.
Sim John J.
|
|
|
Abstract
|
|
|
Background: We sought to evaluate plasma renin activity (PRA) levels and risk of mortality and cardiovascular events among individuals with elevated blood pressure [systolic blood pressure (SBP) ≥ 140 mmHg] and those with controlled blood pressure (SBP < 140 mmHg) in a large diverse population.
Methods: A retrospective cohort study between January 1, 2007, and December 31, 2013, among adults (≥ 18 years) within an integrated health system was conducted. Subjects were categorized by SBP into 2 groups: SBP < 140 mmHg and SBP ≥ 140 mmHg and then further categorized into population-based PRA tertiles within each SBP group. Cox proportional hazard modeling was used to estimate hazard ratios for cardiovascular and mortality outcomes among tertiles of PRA levels.
Results: Among 6,331 subjects, 32.6% had SBP ≥ 140 mmHg. Multivariable hazard ratios and 95% confidence interval for PRA tertiles T2 and T3 compared to T1 in subjects with SBP ≥ 140 mmHg were 1.42 (0.99?2.03) and 1.61 (1.12?2.33) for ischemic heart events; 1.40 (0.93?2.10) and 2.23 (1.53?3.27) for congestive heart failure; 1.10 (0.73?1.68) and 1.06 (0.68?1.66) for cerebrovascular accident; 1.23 (0.94?1.59) and 1.43 (1.10?1.86) for combined cardiovascular events; and 1.39 (0.97?1.99) and 1.35 (0.92?1.97) for all-cause mortality, respectively. Among the SBP < 140 mmHg group, there was no relationship between PRA levels and outcomes.
Conclusion: Higher PRA levels demonstrated increased risk for ischemic heart events and congestive heart failure and a trend toward higher mortality among individuals with SBP ≥ 140 mmHg but not among those with SBP < 140 mmHg.
|
|
|
KEYWORD
|
|
|
Cardiovascular outcomes, Epidemiology, Mortality, Plasma renin activity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|